Chemotherapeutic agents knowledge for medical students. The treatment of cancer using specific chemical agents or drugs that are selectively destructive to malignant cells and tissues. Chapter 12 chemotherapeutic agents flashcards quizlet. Chemotherapeutic agents knowledge for medical students and. Nov, 2014 chemotherapeutic agents and their applications. By contrast, an antibiotic is a product of the metabolism of a microorganism. Containers that held hazardous waste chemotherapy drugs, and do not meet the definition of empty, are hazardous waste when discarded. Control of microbial growth online textbook of bacteriology. As a generator of hazardous waste, you must comply with the applicable requirements in shs. How chemotherapy drugs work american cancer society. Chapter 9 chemotherapeutic agents 02 authorstream presentation. The term generally implies a chemical that has been synthesized by chemists or produced by a modification of a preexisting chemical. Full text full text is available as a scanned copy of the original print version.
Toxicity of chemotherapeutic agents to normal cells is the cause of unpleasant side effects. Since chemotherapeutic drugs cannot distinguish between normal cells and cancer cells, both types of cells are affected by chemotherapy. Definition of chemotherapy nci dictionary of cancer. Here we report differential impacts of 54 anticancer drugs on dc. Tumors are made up of cells that are reproducing at abnormally high rates. Microbial pathogens grow on and within the body of other living beings and their colonization may lead to disease, disability, and death. Chemotherapeutic agent synonyms, chemotherapeutic agent pronunciation, chemotherapeutic agent translation, english dictionary definition of chemotherapeutic agent. New chemotherapeutic agents with more specificity, less toxicity, and the improved ability to halt molecular pathways of tumorigenesis are being developed and need to be optimized.
Chemotherapeutic article about chemotherapeutic by the free. The medical treatment of extravasation is based on proper maintenance of the intravenous iv line and application of cold or warm compresses, plus the use of antidotes when available. General characteristics of chemotherapeutic agents 3. Drugs with different patterns of resistance should be combined to minimize crossresistance. Hazardous waste has specific management requirements for marking, labeling, time limits for storing, transportation, disposal methods and recordkeeping. Sep, 2017 the adverse health effects associated with antineoplastic agents cancer chemotherapy drugs, cytotoxic drugs in cancer patients and some noncancer patients treated with these drugs are well documented.
Both the size and distribution of charge of the sulfonamides and paba molecule are very similar, so sulfa drug play a role of metabolism antagonist. Chemotherapeutic agent definition of chemotherapeutic. Chemotherapy is a type of cancer treatment that uses one or more anticancer drugs chemotherapeutic agents as part of a standardized chemotherapy. Pdf classification of chemotherapeutic agents based on their. An agent used to treat cancer administered in regimens of one or more cycles, combining two or more agents over a period of days to weeks. Medication errors in administration of chemotherapeutic agents. Pdf classification of chemotherapeutic agents based on. Medication errors in administration of chemotherapeutic. Information and translations of chemotherapeutic agent in the most comprehensive dictionary definitions resource on the web. Chemotherapy definition of chemotherapy by merriamwebster. The very nature of antineoplastic agents make them harmful to healthy cells and tissues as well as the cancerous cells. The development of these agents began in the 1940s.
The basics what is chemotherapy and how does it work. Classification of anticancer drugs based on their differential impacts on dcs. Chemotherapy agent an overview sciencedirect topics. Drugs or biologicals and cancer chemotherapeutic agents approved for marketing by the food and drug administration fda are considered safe and effective for purposes of this requirement when used for indications specified on the labeling. Such agents are toxic to cells with high proliferative ratese. This teacherdeveloped 5th grade word list covers all the basics to prepare students for middle school.
Some are cytotoxic, meaning that the drugs damage the cells and prevent them from replicating or increasing in number. Thanks to the development of new, effective chemotherapeutic agents. This is a list of chemotherapeutic agents, also known as cytotoxic agents, that are known to be of use in chemotherapy for cancer. These drugs are very different in their chemical composition, how they are taken, their usefulness in treating specific forms of cancer, and their side effects. Chemotherapy may be given with a curative intent which almost always involves combinations of drugs, or it may aim to prolong life or to reduce symptoms palliative chemotherapy. Cancer chemotherapeutic agents are often given in combination because cellular interactions such as inhibiting cell replication and promoting apoptosis among the drugs cause more cancer cell death. Several novel chemotherapeutics that target specific signaling pathways are now. However, the value of chemotherapy lies in the fact that the killing effect of chemotherapeutic agents has a. Chemotherapeutic agents definitions learn with flashcards, games, and more for free. Chemotherapeutic agent article about chemotherapeutic agent.
Chemotherapeutic agents include substances of natural origin for example, antibiotics and synthetic preparations for example, sulfanilamides, nitrofurans, and paraaminosalicylic acid. Chemotherapeutic agents definitions flashcards quizlet. Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the proliferation of rapidly growing. Among 271 fetuses exposed to chemotherapeutic agents during the first trimester, 19. Chemotherapeutic agents list of high impact articles ppts.
Still, significant challenges remain for specific cancer types, such as glioblastoma, in which a combination of early detection, surgery, chemotherapy, and radiotherapy cannot extend survival beyond 12 years. Chemotherapeutic definition of chemotherapeutic by merriam. Chapter 3 principles of chemotherapy ray page, do, phd, and chris takimoto, md, phd the effective use of cancer chemotherapy requires an understanding of the principles of tumor biology, cellular kinetics, pharmacology, and drug resistance. More than 100 chemotherapy or chemo drugs are used to treat cancer either alone or in combination with other drugs or treatments. Pdf despite the crucial roles dendritic cells dc play in host immunity against. The local delivery of controlled release antimicrobials provides a means of professionally administering chemotherapeutic agents directly into the periodontal pocket in order to provide slow release of the drug. Chemotherapeutic agents and their applications authorstream. Pdf the ideal antimicrobial agent should he nontoxic to the host selective toxicity, nonallergenic, soluble in body fluids, able to be maintained. It is usually used to refer to antineoplastic drugs. Chemotherapeutic agents stateexpanded to show the template expanded, i.
This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Chemotherapeutics definition of chemotherapeutics at. Chemotherapeutics definition of chemotherapeutics by. Chemotherapeutic definition is of, relating to, or used in chemotherapy. Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells article pdf available in cancer research 6917. Most chemotherapeutic agents can cause varying degrees of local tissue injuries when extravasated. Some types of cancer can be treated with just chemotherapy. Antimicrobial, antiparasitic, and antineoplastic chemotherapeutic agents are distinguished. Therefore, payment may be made for an fda approved drug or biological or cancer chemotherapeutic agent if. Chemotherapy may be given by mouth, injection, or infusion, or on the skin, depending on the type and stage of the cancer being treated. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Chapter 10 antibiotics and chemotherapeutic agents. Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the proliferation of rapidly growing cells, typically in the context of malignancy. They are classified according to their mechanism of action and include alkylating agents, antimetabolites, topoisomerase inhibitors, and mitotic.
Other articles where chemotherapeutic agent is discussed. Chemotherapeutic agent definition of chemotherapeutic agent. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Once again, we employed the same dual criteria to define a. In order to understand how these medications work, we need to understand a bit about tumor cells. Chemotherapy may be given with a curative intent which almost always involves combinations of drugs, or it may aim to prolong life. Chemotherapeutic agents are chemical substances used within the body for therapeutic purposes. Terminology used in describing chemotherapy chemotherapy is administered with a variety of treatment schedules designed according to the intent and responsiveness of therapy. Anthracyclines are very efficient chemotherapeutic agents, derivatives of streptomyces peucetius which is a pigment producing bacteria.
It uses special drugs to kill cancer cells in the body. Local coverage article for approved drugs and biologicals. Definition of nonchemotherapeutic in the definitions. Each drug is listed once at present, though it might fall in more than one subsection. Get a printable copy pdf file of the complete article 1. Note that the microbiologists definition of a chemotherapeutic agent requires that the. Treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
Nov 22, 2012 cancer is a disease in which there is uncontrolled multiplication and spread within the body of abnormal forms of bodys own cells. Predisposing factors for laryngeal candidiasis include immunodeficiency syndromes, immunosuppressive medications e. Chemotherapeutic agent legal definition of chemotherapeutic agent. Chemotherapy often abbreviated to chemo and sometimes ctx or ctx is a type of cancer treatment that uses one or more anticancer drugs chemotherapeutic agents as part of a standardized chemotherapy regimen. The ideal antimicrobial agent should he nontoxic to. With the direct placement of the drug in the periodontal pocket, the chance of drug resistance is. It includes alkylating agents, antimetabolites, antitumor antibiotics, anthracyclines, topoisomerase inhibitors, etc. Chemotherapeutic agents and their applications balaji college of pharmacy mr. Antihypertensive drugs are often given in combination because some of the side effects.
Sep 28, 2019 chemotherapeutic plural chemotherapeutics medicine, oncology a chemical agent used in chemotherapy 2005, michael g. Chemotherapeutic definition of chemotherapeutic by the free. They are classified according to their mechanism of action and include alkylating agents, antimetabolites, topoisomerase inhibitors, and mitotic inhibitors. Classification of chemotherapeutic agents based on their differential. Pdf antibiotics and chemotherapeutic agents researchgate. Chemotherapy definition is the therapeutic use of chemical agents to treat disease. Chemotherapeutic agents are also known as cytotoxic agents. Ongoing treatment strategies include combining chemotherapy with targeted molecular therapeutic agents, antiangiogenic treatments, and biologicals. Information and translations of nonchemotherapeutic in the most comprehensive dictionary definitions resource on the web.1022 733 1207 1471 569 678 796 752 447 724 427 1198 1033 1157 1466 681 239 837 948 189 173 1283 755 1336 1189 1015 534 1526 588 1248 939 291 1411 384 1102 277 377 1132 6 912 1055